Marco Magalhaes

Biography

Marco Magalhaes DDS, MSc, PhD, FRCDC Assistant Professor Contact information Faculty of Dentistry University of Toronto 124 Edward St., Rm 511A Toronto Ontario M5G 1X3 Phone: 416-979-4920 Ext: 4485 Fax: 416-979-4938 Email: marco.magalhaes@utoronto.ca Research location: University of Toronto - St. George Campus (downtown) Primary Research Area: Cancer Secondary Research Area: Molecular & Cell Biology Research Statement: The Cancer Invasion and Metastasis laboratory (CIMlab) uses a combination of cell biology, leading edge imaging techniques and clinical studies to investigate the mechanisms of early cancer invasion.                                                       Marco Magalhaes DDS, MSc, PhD, FRCDC Assistant Professor Contact information Faculty of Dentistry University of Toronto 124 Edward St., Rm 511A Toronto Ontario M5G 1X3 Phone: 416-979-4920 Ext: 4485 Fax: 416-979-4938 Email: marco.magalhaes@utoronto.ca Research location: University of Toronto - St. George Campus (downtown) Primary Research Area: Cancer Secondary Research Area: Molecular & Cell Biology Research Statement: The Cancer Invasion and Metastasis laboratory (CIMlab) uses a combination of cell biology, leading edge imaging techniques and clinical studies to investigate the mechanisms of early cancer invasion.                                                      

Research Interest

Cancer invasion underlies the most severe complications and is responsible for most of the morbidity and mortality of cancers. Therefore, developing strategies to detect early invasion is essential to establish appropriate treatment and increase survival. The CIMlab focuses on the study of  invadopodia-dependent invasion as these are specialized actin-rich structures that are unique to cancer cells and mediate invasion. Oral squamous cell carcinoma (OSCC) is a devastating disease and its poor prognosis has changed minimally in the past several decades. The Canadian cancer statistics estimates that in 2015, 4,400 people will be diagnosed with oral cancer in Canada and 1,200 deaths will occur as a result of the disease.