Bernard P. Duncker
Professor
Biology
University of Waterloo
Canada
Biography
Prof/Dr. Bernard Duncker carries out cancer-related research on yeast and is an expert on the initiation of eukaryotic DNA replication and cell cycle checkpoints. His work on the budding yeast Saccharomyces cerevisiae and the proteins involved in controlling DNA replication has applications for developing biomarkers to detect the presence of environmental carcinogens, and cancer in humans. Professor Duncker is also studying how both yeast and various fish species regulate the production of certain proteins during cell cycle checkpoints, a series of decisions involved in cell proliferation which become flawed as cells turn cancerous. PhD Biology, Queen's University , 1995. University of Waterloo Outstanding Performance Award,2008 and 2013. 2005-2010 Ontario Early Researcher Award, 2003-2009 Canadian Cancer Society Research Scientist Award. Member of Canadian Society for Molecular Biosciences.
Research Interest
DNA replication Cell cycle checkpoints Molecular Genetics
Publications
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Liu M, Tee C, Zeng F, Sherry JP, Dixon B, Bols NC, Duncker BP. Characterization of p53 expression in rainbow trout. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology. 2011 Nov 30;154(4):326-32.
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Ramer MD, Suman ES, Richter H, Stanger K, Spranger M, Bieberstein N, Duncker BP. Dbf4 and Cdc7 proteins promote DNA replication through interactions with distinct Mcm2–7 protein subunits. Journal of Biological Chemistry. 2013 May 24;288(21):14926-35.
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Matthews LA, Selvaratnam R, Jones DR, Akimoto M, McConkey BJ, Melacini G, Duncker BP, Guarné A. A novel non-canonical forkhead-associated (FHA) domain-binding interface mediates the interaction between Rad53 and Dbf4 proteins. Journal of Biological Chemistry. 2014 Jan 31;289(5):2589-99.
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Almawi AW, Matthews LA, Myrox P, Boulton S, Lai C, Moraes T, Melacini G, Ghirlando R, Duncker BP, Guarné A. ‘AND’logic gates at work: Crystal structure of Rad53 bound to Dbf4 and Cdc7. Scientific reports. 2016 Sep 29;6:34237.
