Jamie W. Joseph
Associate Professor
Biology
University of Waterloo
Canada
Biography
Dr. Joseph, received his PhD Physiology (University of Toronto). He is currently working as Associate Professor In University of Waterloo.His research is focused on ascertaining how the β-cell senses glucose and on searching for ways to reduce the number of islets required for islet transplantation. These two themes are connected in that the first theme provides novel targets to enhance islet function in the second theme. His long-term goals are to discover novel drug targets for enhancing islet function to treat type 2 diabetes and to develop a renewable source of β-cells (e.g., cell therapy) to treat both type 1 and type 2 diabetes.
Research Interest
"Drug Discovery Molecular Pharmacology Diabetes"
Publications
-
Wilkins HM, Kirchhof D, Manning E, Joseph JW, Linseman DA. Mitochondrial glutathione transport is a key determinant of neuronal susceptibility to oxidative and nitrosative stress. Journal of Biological Chemistry. 2013 Feb 15;288(7):5091-101.
-
Koulajian K, Desai T, Liu GC, Ivovic A, Patterson JN, Tang C, El-Benna J, Joseph JW, Scholey JW, Giacca A. NADPH oxidase inhibition prevents beta cell dysfunction induced by prolonged elevation of oleate in rodents. Diabetologia. 2013 May 1;56(5):1078-87.
-
Fox JE, Seeberger K, Dai XQ, Lyon J, Spigelman AF, Kolic J, Hajmrle C, Joseph JW, Kin T, Shapiro AJ, Korbutt G. Functional plasticity of the human infant β-cell exocytotic phenotype. Endocrinology. 2013 Feb 28;154(4):1392-9.
