Stephanie Dewitte-orr
Assistant Professor
Biology
University of Waterloo
Canada
Biography
Dr. Stephanie DeWitte-Orr, received her PhD Department of Biology, University of Waterloo. Currently She is working as Assistant Professor in Water loo University.Her investigates innate immune responses to virus infections, specifically focusing on how animals respond to viral double-stranded (ds) RNA. This work has applications for developing antiviral drugs and vaccine adjuvants.
Research Interest
Immune responses to virus infections, viral double-stranded (ds) RNA
Publications
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DeWitte-Orr SJ, Mehta DR, Collins SE, Suthar MS, Gale M, Mossman KL. Long double-stranded RNA induces an antiviral response independent of IFN regulatory factor 3, IFN-β promoter stimulator 1, and IFN. The Journal of Immunology. 2009 Nov 15;183(10):6545-53.
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DeWitte-Orr SJ, Leong JA, Bols NC. Induction of antiviral genes, Mx and vig-1, by dsRNA and Chum salmon reovirus in rainbow trout monocyte/macrophage and fibroblast cell lines. Fish & shellfish immunology. 2007 Sep 30;23(3):670-82.
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DeWitte-Orr SJ, Collins SE, Bauer CM, Bowdish DM, Mossman KL. An accessory to the ‘Trinity’: SR-As are essential pathogen sensors of extracellular dsRNA, mediating entry and leading to subsequent type I IFN responses. PLoS pathogens. 2010 Mar 26;6(3):e1000829.
