Dr. Chris J. Brandl
Professor
Department of Biochemistry
University of Western Ontario
Canada
Biography
Dr. Chris J. Brandl received his Post-doctoral researcher, Harvard Medical School, he is a Professor of Biochemistry at university of Western Ontario, Canada.
Research Interest
Determining the role of Tra1p, a 430 kDa component of the complexes that is related to a group of key cellular protein kinases. Interestingly as well as being required for transcriptional regulation Tra1 is required for telomere elongation. The mechanism by which the SAGA component protein Ada2 regulates the histone acetyltransferase activity of Gcn5. Of note, Ada2 also has molecular connections with nuclear pore function. The role of post-translational modification and processing of components of the SAGA complex.
Publications
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Stead BE, Brandl CJ, Sandre MK, Davey MJ. Mcm2 phosphorylation and the response to replicative stress. BMC genetics. 2012 May 7;13(1):36.
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Innes BT, Bailey ML, Brandl CJ, Shilton BH, Litchfield DW. Non-catalytic participation of the Pin1 peptidyl-prolyl isomerase domain in target binding. Frontiers in physiology. 2013;4:18-.
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DaSilva LF, Pillon S, Genereaux J, Davey MJ, Gloor GB, Karagiannis J, Brandl CJ. The C-terminal residues of Saccharomyces cerevisiae Mec1 are required for its localization, stability, and function. G3: Genes, Genomes, Genetics. 2013 Oct 1;3(10):1661-74.
