Dr. Hong Ling
Professor
Department of Biochemistry
University of Western Ontario
Canada
Biography
Dr. Hong Ling, Ph.D., University of Alberta, Postdoctoral Fellow, NIH, Professor of Biochemistry in University of Western Ontario, Canada.
Research Interest
Research in my laboratory focuses on identifying the molecular mechanisms of DNA damage and how this is properly managed in cells. In particular, we study biological responses to DNA damage and mutagenesis caused by endogenous and environmental DNA-damaging agents, which have broad implications in cancer. To reach our research goals, we use X-ray crystallography to determine protein structures, combined with molecular biology, cell biology, protein chemistry and other biophysical methods.
Publications
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Kirouac KN, Ling H. Unique active site promotes error-free replication opposite an 8-oxo-guanine lesion by human DNA polymerase iota. Proceedings of the National Academy of Sciences. 2011 Feb 22;108(8):3210-5.
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Kirouac KN, Basu AK, Ling H. Replication of a carcinogenic nitropyrene DNA lesion by human Y-family DNA polymerase. Nucleic acids research. 2012 Dec 24;41(3):2060-71.
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Jha V, Bian C, Xing G, Ling H. Structure and mechanism of error-free replication past the major benzo [a] pyrene adduct by human DNA polymerase κ. Nucleic acids research. 2016 Jun 2;44(10):4957-67.
