Dr. Michael B. Boffa
Associate Professor
Department of Biochemistry
University of Western Ontario
Canada
Biography
Dr. Michael B. Boffa received his Ph.D. Queen's University, he is a Associate Professor of Clinical Biochemist at university of Western Ontario, Canada.
Research Interest
My research group is pursuing studies of structure/function relationships in TAFI, using molecular biological and protein biochemical approaches. We are particularly interested in a hallmark feature of TAFIa: unlike most proteins, the enzyme is intrinsically unstable and the spontaneous loss of its activity is a key regulatory property. We also have a major focus on the role of TAFI in breast cancer metastasis, which we are pursuing using biochemical, cell biological, and animal model approaches. Finally, we have made key contributions to the understanding of the mechanisms of regulation of the gene encoding TAFI, and we are continuing to pursue new avenues of research in this realm.
Publications
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Scipione CA, McAiney JT, Simard DJ, Bazzi ZA, Gemin M, Romagnuolo R, Macrae FL, Ariëns RA, Hegele RA, Auld J, Gauld JW. Characterization of the I4399M variant of apolipoprotein (a): Implications for altered prothrombotic properties of lipoprotein (a). Journal of Thrombosis and Haemostasis. 2017 Sep 1.
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Romagnuolo R, Scipione CA, Marcovina SM, Gemin M, Seidah NG, Boffa MB, Koschinsky ML. Roles of the low density lipoprotein receptor and related receptors in inhibition of lipoprotein (a) internalization by proprotein convertase subtilisin/kexin type 9. PloS one. 2017 Jul 27;12(7):e0180869.
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Ellis KL, Boffa MB, Sahebkar A, Koschinsky ML, Watts GF. The renaissance of lipoprotein (a): Brave new world for preventive cardiology?. Progress in Lipid Research. 2017 Sep 6.
