Dr. Nathalie Berube
Associate Professor (Biochemistry and Paediatrics)
Department of Biochemistry
University of Western Ontario
Canada
Biography
Dr. Nathalie Berube received his Ph.D. University of Ottawa, he is a Associate Professor (Biochemistry and Paediatrics), Scientist, Children's Health Research Institute at university of Western Ontario, Canada.
Research Interest
We examine disorders of chromatin structure using mouse and cell models that lack specific chromatin remodelling proteins. Representative examples include ATR-X syndrome (ATRX protein) and Rett syndrome (MeCP2 protein). Our studies will provide insight into the molecular, cellular, and behavioural defects effected by these syndromes and hold promise for therapeutics to alleviate symptoms of these defects.
Publications
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Ritchie K, Watson LA, Davidson B, Jiang Y, Bérubé NG. ATRX is required for maintenance of the neuroprogenitor cell pool in the embryonic mouse brain. Biology open. 2014 Dec 15;3(12):1158-63.
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Levy MA, Kernohan KD, Jiang Y, Bérubé NG. ATRX promotes gene expression by facilitating transcriptional elongation through guanine-rich coding regions. Human molecular genetics. 2014 Dec 1;24(7):1824-35.
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Bush JR, Bérubé NG, Beier F. A new prescription for growth? Statins, cholesterol and cartilage homeostasis. Osteoarthritis and cartilage. 2015 Apr 1;23(4):503-6.
