Dr. Peter Merrifield
Associate Professor and Associate Scientist, Child
Department of Medicine
University of Western Ontario
Canada
Biography
Dr. Peter Merrifield , Associate Professor and Associate Scientist, Child Health Research Institute Department of Medicine at University of Western Ontario, Canada. Ph.D. University of Western Ontario .
Research Interest
Skeletal muscle development, or myogenesis, represents an ideal model system for studying cellular processes such as cell migration, cell signaling, cell cycle regulation and cell differentiation. Understanding myogenesis is extremely important, since myoD -/-, myf5 -/- deficient mice which lack normal muscle development die at birth, and mutant mice lacking muscle specific stem cells (or satellite cells) cannot regenerate muscle in response to injury. The objective of my current research program is to elucidate the cell signaling and epigenetic mechanisms which commit muscle precursor cell to specific myogenic lineages and the role of specific myogenic lineages in the development and regeneration of different muscle fibre types. Specifically, I am using several different rodent models.
Publications
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Jin Y, Kong H, Stodilka RZ, Wells RG, Zabel P, Merrifield PA, Sykes J, Prato FS. Determining the minimum number of detectable cardiac-transplanted 111In-tropolone-labelled bone-marrow-derived mesenchymal stem cells by SPECT. Physics in medicine and biology. 2005 Sep 14;50(19):4445.
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Blackwood KJ, Sabondjian E, Goldhawk DE, Kovacs MS, Wisenberg G, Merrifield P, Prato FS, DeMoor JM, Stodilka RZ. Towards Image-Guided Stem Cell Therapy. Progress in stem cell applications. New York: Nova Science. 2008:153-80.
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Wisenberg G, Lekx K, Zabel P, Kong H, Mann R, Zeman PR, Datta S, Culshaw CN, Merrifield P, Bureau Y, Wells G. Cell tracking and therapy evaluation of bone marrow monocytes and stromal cells using SPECT and CMR in a canine model of myocardial infarction. Journal of Cardiovascular Magnetic Resonance. 2009 Apr 27;11(1):11.
