Dr. Victor Han
Professor and Canada Research Chair
Department of Medicine
University of Western Ontario
Canada
Biography
Dr. Victor Han is a M.D. University of Rangoon, Dr. Han’s laboratory is focused on studying the molecular and cellular mechanisms of normal fetal and placental growth with the aim of understanding the pathobiological mechanisms of fetal growth restriction and preeclampsia. His laboratory utilizes (1) transgenic and gene targeting technologies to delineate the paracrine/endocrine role of IGF system in mice, (2) models of manipulating nutritional and substrate supplies to the fetus in pregnant animals to study gene-environmental interactions in fetal and placental development and developmental programming, and (3) genomic and proteomic technologies to determine the molecular mechanisms of fetal growth restriction and preeclampsia in biological materials (plasma, amniotic fluid and placentae) from human subjects. The ultimate aim of Dr. Han’s research is to develop new diagnostic tools and interventions to improve the short- and long-term outcomes of women who develop preeclampsia during pregnancies, and growth restricted (low birth weight) newborns.
Research Interest
(1) transgenic and gene targeting technologies to delineate the paracrine/endocrine role of IGF system in mice, (2) models of manipulating nutritional and substrate supplies to the fetus in pregnant animals to study gene-environmental interactions in fetal and placental development and developmental programming, and (3) genomic and proteomic technologies to determine the molecular mechanisms of fetal growth restriction and preeclampsia in biological materials (plasma, amniotic fluid and placentae) from human subjects.
Publications
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Seferovic MD, Ali R, Kamei H, Liu S, Khosravi JM, Nazarian S, Han VK, Duan C, Gupta MB. Hypoxia and leucine deprivation induce human IGFBP-1 hyper-phosphorylation and increase its biological activity. Endocrinology. 2008.
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Abu Shehab M, Inoue S, Han VK, Gupta MB. Site specific phosphorylation of insulin-like growth factor binding protein-1 (IGFBP-1) for evaluating clinical relevancy in fetal growth restriction. Journal of proteome research. 2009 Oct 8;8(11):5325-35.
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Iosef C, Vilk G, Gkourasas T, Lee KJ, Chen BP, Fu P, Bach LA, Lajoie G, Gupta MB, Li SS, Han VK. Insulin-like growth factor binding protein-6 (IGFBP-6) interacts with DNA-end binding protein Ku80 to regulate cell fate. Cellular signalling. 2010 Jul 31;22(7):1033-43.
