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Rob Hegele

Scientist
Department of Biochemistry
University of Western Ontario
Canada

Biography

I attended the University of Toronto and received my medical degree in 1981. Specialty training in Internal Medicine and Endocrinology was followed by four years of post-doctoral training, first at the Rockefeller University, New York City, in heart disease and cholesterol, and then in human genetics at the Howard Hughes Medical Institute in Salt Lake City, Utah. It was during my research fellowship in New York City that I became inspired to pursue research in genetics. With a strong belief in the power of human genetics and genomics to help solve fundamental problems related to human health and disease, my lab began researching the genetic basis of several human disorders, most notably several forms of dyslipidemia (high cholesterol) and type 2 diabetes.

Research Interest

Rob Hegele is Distinguished University Professor of Medicine and Biochemistry, Western University, and Director of London Regional Genomics Centre at Robarts Research Institute. He holds the Wolfe Distinguished Medical Research Chair, the Edith Schulich Vinet Chair in Human Genetics and the Blackburn Chair in Cardiovascular Research.

Publications

  • Lee JH, Giannikopoulos P, Duncan SA, Wang J, Johansen CT, Brown JD, Plutzky J, Hegele RA, Glimcher LH, Lee AH. The transcription factor cyclic AMP-responsive element-binding protein H regulates triglyceride metabolism. Nature medicine. 2011 Jul 1;17(7):812-5.

  • Hegele RA. Plasma lipoproteins: genetic influences and clinical implications. Nature Reviews Genetics. 2009 Feb 1;10(2):109-21.

  • Joy TR, Hegele RA. Narrative review: statin-related myopathy. Annals of Internal Medicine. 2009 Jun 16;150(12):858-68.

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