Sashko Damjanovski, Phd Associate Profes
Sashko Damjanovski, PhD Associate Professor
Department of Biology
University of Western Ontario
Canada
Biography
Sashko Damjanovski, PhD Associate Professor of Department of Biology at university of Western Ontario, Canada.
Research Interest
Currently we are focusing on a membrane bound MMP named MT1-MMP. MT1-MMP appears to be a key lynch-pin in several processes as it is believed to not only regulate ECM remodelling, but also to activate other MMPs, transduce signalling cascades, as well as impact cellular viability. Understanding this regulation would be crucial in our understanding of the roles that these molecules play in development and disease.
Publications
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Cepeda MA, Pelling JJ, Evered CL, Leong HS, Damjanovski S. The cytoplasmic domain of MT1-MMP is dispensable for migration augmentation but necessary to mediate viability of MCF-7 breast cancer cells. Experimental cell research. 2017 Jan 1;350(1):169-83.
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Cepeda MA, Evered CL, Pelling JJ, Damjanovski S. Inhibition of MT1-MMP proteolytic function and ERK1/2 signalling influences cell migration and invasion through changes in MMP-2 and MMP-9 levels. Journal of cell communication and signaling. 2017 Jun 1;11(2):167-79.
