Shiva Singh, Phd
Professor (Distinguished University Professor), Mo
Department of Biology
University of Western Ontario
Canada
Biography
Shiva Singh, PhD Professor (Distinguished University Professor), Molecular Genetics of Complex Diseases and Phenotype, of Department of Biology at the University of Western Ontario, Canada.
Research Interest
Our research program on genetic variation including human molecular genetics deals with genetic and epigenetic factors associated with complex diseases and phenotypes with a focus on neurogenomics. It using whole genome based methods (microarrays; expressed, SNPs and methylation specific oligonucleotide microarrays and complete genome sequences) in studies on Schizophrenia, Alcoholism, Fetal Alcohol Syndrome and Cancers. They involve human families including monozygotic twins discordant for the disease and mouse as the genetic animal model. The results obtained have offered a novel insight, particularly the importance of epigenetics and gene regulation in the dissection of behaviors. This novelty is recognized by the genetics community including granting agencies (NSERC, NAMI (NIH), CIHR, ATCG, OMHF, SSO, etc.) who have funded this research fully and adequately for over 35 years.
Publications
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Castellani CA, Melka MG, Gui JL, O'Reilly RL, Singh SM. Integration of DNA sequence and DNA methylation changes in monozygotic twin pairs discordant for schizophrenia. Schizophrenia research. 2015 Dec 31;169(1):433-40.
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Alberry B, Singh SM. Developmental and behavioral consequences of early life maternal separation stress in a mouse model of fetal alcohol spectrum disorder. Behavioural brain research. 2016 Jul 15;308:94-103.
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Chater-Diehl EJ, Laufer BI, Castellani CA, Alberry BL, Singh SM. Alteration of gene expression, DNA methylation, and histone methylation in free radical scavenging networks in adult mouse hippocampus following fetal alcohol exposure. PloS one. 2016 May 2;11(5):e0154836. q
