Microbiology & Immunology
MUHC Research Institute, 1001 Boul. Decarie
My laboratory is involved in identifying the molecular mechanisms whereby pathogenic fungi cause human disease. Our work focuses on two pathogens, Candida albicans and Aspergillus fumigatus, both of which cause fatal infections in immunocompromised hosts. The adherence of these organisms to host tissues, especially vascular endothelial cells is a critical step in the pathogenesis of infection, and our work has begun to elucidate the fungal adhesins involved in this process and the genetic pathways controlling their expression.
7th Advances Against Aspergillosis: Basic, diagnostic, clinical and therapeutic studies. Cramer RA, Sheppard DC, Clemons KV.
Serious fungal infections in Canada. Dufresne SF, Cole DC, Denning DW, Sheppard DC.
Microbial glycoside hydrolases as antibiofilm agents with cross-kingdom activity. Snarr BD, Baker P, Bamford NC, Sato Y, Liu H, Lehoux M, Gravelat FN, Ostapska H, Baistrocchi SR, Cerone RP, Filler EE, Parsek MR, Filler SG, Howell PL, Sheppard DC.