Chen Hua
Professor
Laboratory of Genome Sciences & Information
Beijing Institute of Genomics
China
Biography
Dr. CHEN Hua is a professor and principal investigator of the Population Genetics and Computational Genomics Group at Beijing Institute of Genomics (BIG), Chinese Academy of Sciences (CAS). Dr. Chen received the B.S. and M.S. degrees in Genetics from Fudan University, Shanghai, China in 2001. He received a Ph.D. in Integrative Biology (with emphasis in Computational Genomic Biology) from University of California, Berkeley, USA in December 2007 (advisor: Dr. Montgomery Slatkin). Dr. Chen did postdoctoral research in Harvard Medical School and School of Public Health, and the Broad Institute. He was a research assistant professor in Temple University, USA before joining BIG. Dr. Chen’s expertise is theoretical population genetics. His recent work includes coalescent theory for the joint allele frequency spectrum, the asymptotic coalescent distributions and statistical methods for detecting natural selection (hidden Markov model, XP-CLR etc)
Research Interest
Computational Genomics, Population Genetics, allele
Publications
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ana K., Wang S., Tan J., Gerbault P., Wark A., Tan L., Yang Y., Li S., Tang K.,Chen H., Powell A., Itan Y., Fuller D., Lohmueller J., Mao J., Schachar A., Paymer M., Hostetter E., Byrne E., Burnett E., McMahon AP., Thomas MG., Lieberman DE., Jin L., Tabin CJ., Morgan BA. and Sabeti PC. (2013). Modeling Recent Human Evolution in Mice by Expression of a Selected EDAR Variant. Cell. 152 (4): 691-702.
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Chen H*. (2015). Population genetic studies in the genomic sequencing era. Zoological Research. 36(1): 1-11.
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.Macholdt E., Lede V., Barbieria C., Mpolokab SW., Chen H., Slatkin M., Pakendorfd B., and Stoneking M. (2014). Tracing prehistoric pastoralist migrations: lactase persistence alleles in southern Africa. Current Biology. 24(8): 875-879.
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Chen H*, Hey J, Chen K. (2015). Inferring Very Recent Population Growth Rate from Population-Scale Sequencing Data: Using a Large-Sample Coalescent Estimator. Molecular Biology and Evolution. 32(11):2996-3011.
