Wu, Lingqian

Biography

Investigation of the pathogenic mechanism of mental retardation (MR); standardization and application of new technology in diagnosis for genetic disorders; study of noninvasive approaches for prenatal diagnosis; investigation of human assisted reproductive technology Mapping, identification and functional research of the genes associated with mental retardation. Investigation in a large panel of idiopathic MR patients by genome-wide CNV detection of SNP array, FISH, RT-PCR, fine mapping. Identification of genes associated with MR and functional study of the pathogenic mechanism. Etiological diagnosis and genetic counseling for the patients and their families.Establishment and evaluation of prenatal diagnosis system for chromosomal and severe mono-genetic disorders Integrated application of techniques for High-Tech prenatal diagnosis to control birth defects. Effects of micromanipulation on human embryonic development.Evaluation and improvement of micromanipulation (micro-insemination, assisted hatching of embryo and blastomere biopsy) of human embryo by modifying and comparing with the traditional approach. Noninvasive prenatal diagnosis for chromosomal aneuploid by detecting free DNA of fetus in maternal peripheral blood.

Research Interest

mental retardation, genetic disorders