Aike Guo

Biography

1960-1965  Dept. of  Biophysics, Moscow University, (USSR). 1977-1979  Dr. rer. nat. Munich University, Germany 1982-1984  Visiting Scientist (Max-Planck Institute for Biological Cybernetics, Germany) 1988-  Research Professor, Institute of Biophysics, CAS. 2003-  Academician of the Chinese Academy of Sciences 2006　was awarded The Science and Technology Advancement Award of the Ho Leung Ho Lee Foundation 2006.3 was elected the  Advanced Scientist of CAS 2008    was awarded the 2008 Distinguished Scientist Award of Asia pacific Neural Network Assembly 2000-2005  the principal researcher of State 973 projects (Major State Basic Research Program Grant) “Brain Development and Plasticity” 2006-2008  the principal researcher of State 973 projects “Brain Plasticity in Structure and Function” 2012-  Principal Scientist for the Strategic Priority Research Program (B) of the Chinese Academy of Sciences: Mapping Functional Brain Connections Project 1960-1965  Dept. of  Biophysics, Moscow University, (USSR). 1977-1979  Dr. rer. nat. Munich University, Germany 1982-1984  Visiting Scientist (Max-Planck Institute for Biological Cybernetics, Germany) 1988-  Research Professor, Institute of Biophysics, CAS. 2003-  Academician of the Chinese Academy of Sciences 2006　was awarded The Science and Technology Advancement Award of the Ho Leung Ho Lee Foundation 2006.3 was elected the  Advanced Scientist of CAS 2008    was awarded the 2008 Distinguished Scientist Award of Asia pacific Neural Network Assembly 2000-2005  the principal researcher of State 973 projects (Major State Basic Research Program Grant) “Brain Development and Plasticity” 2006-2008  the principal researcher of State 973 projects “Brain Plasticity in Structure and Function” 2012-  Principal Scientist for the Strategic Priority Research Program (B) of the Chinese Academy of Sciences: Mapping Functional Brain Connections Project

Research Interest

He has established the first Laboratory of Learning /Memory of Drosophila in China at IBP in1993. He has been engaged in the study about the learning, memory, selective attention, decision making, circadian clock, sleep and memory relationship, male-male courtship, as well as the neurodegenerations in flies. His current and future research interests are focusing on goal-directed behaviors or value-guided behavior to identify core neural circuits of how the brain selects the right behavior from the cost and benefit expectations for the behavioral options. His Lab discovered a simple value based decision-making behavior in Drosophila facing competing visual cues at flight simulator and found that Dopamine-Mushroom body circuit regulate decision-making process in Drosophila (Science,2001; Science 2007). His Lab also found that previous experience can enhance visual feature extraction among combinatorial features and that MBs are required for this experience-dependent visual cognition (J. Neurosci, 2007) and that increased dopamine level enhances male-male courtship in Drosophila (J. Neurosci, 2008). They found that a GABAergic inhibitory neural circuit regulates both visual and olfactory reversal learning in Drosophila (J. Neurosci, 2012; Learning and Memory,2012). Recently, his Lab discovered that two clusters of GABAergic Ellipsoid Body neurons modulate olfactory labile memory (J. Neurosci, 2013). And their results revealed parallel pathways for cross-modal memory retrieval in Drosophila (J. Neurosci, 2013). They discovered that “Transformation of odor selectivity from projection neuron inputs to single mushroom body neurons mapped with dual-color calcium imaging” ( Proc Natl Acad Sci U S A,2013). Very recently, they found that Gap Junction networks in mushroom bodies participate in visual learning and memory in Drosophila (eLife, 2016)