Baidong Hou
Professor
Institute of Biophysics
Chinese Academy of Sciences
China
Biography
1989-1994: B.S., Beijing Medical University, Beijing, China 1994-1997: Medical Resident, Peking Union Medical College Hospital, Beijing, China 1997-2001: M.D., Peking Union Medical College, Beijing, China 2001-2003: Postdoctoral fellow, Vanderbilt University, Nashville, TN, USA 2003-2009: Postdoctoral fellow, University of California, San Francisco, CA, USA 2009-2011：Associate specialist, University of California, San Francisco, CA, USA 2011 to present: Professor, Institute of Biophysics, Chinese Academy of Science, Beijing, China Nov. 2011:　supported by the Young Thousand Talents Program
Research Interest
1) Anti-viral antibody response 2) Antibody response in autoimmunity 3) Regulation of B cell differentiation 4) Novel vaccine and immune therapy Antibody is the most important effector molecules of the immune system, which plays critical role in host defense against infection, and is the most commonly used tool in immune therapy. Our research team are focusing on the mechanism by which antibody is generated in viral infection and autoimmune diseases. Our goal is to use the knowledge learnt in the basic research to develop novel vaccines and strategy for immune therapy.
Publications
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3. van Lieshout MH, Anas AA, Florquin S, Hou B, Van't Veer C, de Vos AF, van der Poll T. Hematopoietic but Not Endothelial Cell MyD88 Contributes to Host Defense during Gram-negative Pneumonia Derived Sepsis. PLoS Pathog. 2014 Sep 25;10(9):e1004368. PMID: 25254554
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2. Jackson SW, Jacobs HM, Arkatkar T, Dam EM, Scharping NE, Kolhatkar NS, Hou B, Buckner JH, Rawlings DJ. B cell IFN-γ receptor signaling promotes autoimmune germinal centers via cell-intrinsic induction of BCL-6. J Exp Med. 2016 May 2;213(5):733-50. PMID: 27069113
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1. Liao W, Hua Z, Liu C, Lin L, Chen R, Hou B*. Characterization of T-Dependent and T-Independent B Cell Responses to a Virus-like Particle. J Immunol. 2017 May 15. PMID:28416599
