Chang Chen

Biography

1986-1990  B.S.,  Nankai University, Tianjin, China 1990-1993  M.S.,  Beijing Normal University, Beijing, China 1993-1996  Ph.D.,  Peking University, Beijing, China 1996-1998  Assistant Professor, Institute of Biophysics, CAS 1998-2000  Associate Professor, Institute of Biophysics, CASVisiting Scientist in the Institute of Food Research, Norwich, UK (The Royal Society K.C. Wong Research Fellowship) 2000-Present  Principle Investigator (PI ) (2004, full professor. Institute of Biophysics, CAS.) 2004-2005  Visiting Scientist, Center for Cancer Research, the Medical Research Council, Cambridge, UK Professional activities Vice Director of National Laboratory of Biomacromolecules Professor of University of Chinese Academy of Sciences Chief Scientist of “National Basic Research Program of China, 973 Program” Vice President of the Commission for Free Radical Biology and Medicine of the Biophysical Society of China Council Member of International Society for Free Radical Research, -Asia Editorial Board Member, Free Radical Research and Redox Biology Associate Editor, Acta Biophysica Sinica Deputy General Secretaryn and executive member of the council of The Biophysical Society of China Council Member of The Chinese Society of Biochemistry and Molecular Biology Awards and Honors 2015  Special Government Allowances of the State Council 2014  Outstanding Contribution, CAS-Beijing 2012  National Outstanding Young Scientists 2006  Young Scientist Award Society for Free Radical Research (SFRR)-Asia 1986-1990  B.S.,  Nankai University, Tianjin, China 1990-1993  M.S.,  Beijing Normal University, Beijing, China 1993-1996  Ph.D.,  Peking University, Beijing, China 1996-1998  Assistant Professor, Institute of Biophysics, CAS 1998-2000  Associate Professor, Institute of Biophysics, CASVisiting Scientist in the Institute of Food Research, Norwich, UK (The Royal Society K.C. Wong Research Fellowship) 2000-Present  Principle Investigator (PI ) (2004, full professor. Institute of Biophysics, CAS.) 2004-2005  Visiting Scientist, Center for Cancer Research, the Medical Research Council, Cambridge, UK Professional activities Vice Director of National Laboratory of Biomacromolecules Professor of University of Chinese Academy of Sciences Chief Scientist of “National Basic Research Program of China, 973 Program” Vice President of the Commission for Free Radical Biology and Medicine of the Biophysical Society of China Council Member of International Society for Free Radical Research, -Asia Editorial Board Member, Free Radical Research and Redox Biology Associate Editor, Acta Biophysica Sinica Deputy General Secretaryn and executive member of the council of The Biophysical Society of China Council Member of The Chinese Society of Biochemistry and Molecular Biology Awards and Honors 2015  Special Government Allowances of the State Council 2014  Outstanding Contribution, CAS-Beijing 2012  National Outstanding Young Scientists 2006  Young Scientist Award Society for Free Radical Research (SFRR)-Asia

Research Interest

Reactive oxygen species and reactive nitrogen species (ROS and RNS) have critical biological functions essential for normal physiology. However, overproduction or deficiency result in impaired homeostasis and is associated with pathology, such as ageing-related diseases, malignant transformation, atherosclerosis, neurodegenerative diseases, obesity, and diabetes. Our research has been focused on the crosstalk between these small molecules and macromolecules, trying to explore the relationship between protein function and cellular redox status. We aim to explore the relationship between protein function and cellular redox status, which is one fundamental question in Redox Biology. To reach this goal, we are going to demonstrate cellular Redox network, draw cellular Redox map and illustrate Redox response including oxidative stress and reductive stress. Based on it, try to find out effective approach, such as Chinese medicine, to maintain cellular redox homeostasis and apply for healthy aging and treatment for redox related disease.