Chang Chen
Professor
Institute of Biophysics
Chinese Academy of Sciences
China
Biography
1986-1990 B.S., Nankai University, Tianjin, China 1990-1993 M.S., Beijing Normal University, Beijing, China 1993-1996 Ph.D., Peking University, Beijing, China 1996-1998 Assistant Professor, Institute of Biophysics, CAS 1998-2000 Associate Professor, Institute of Biophysics, CASVisiting Scientist in the Institute of Food Research, Norwich, UK (The Royal Society K.C. Wong Research Fellowship) 2000-Present Principle Investigator (PI ) (2004, full professor. Institute of Biophysics, CAS.) 2004-2005 Visiting Scientist, Center for Cancer Research, the Medical Research Council, Cambridge, UK
Research Interest
Reactive oxygen species and reactive nitrogen species (ROS and RNS) have critical biological functions essential for normal physiology. However, overproduction or deficiency result in impaired homeostasis and is associated with pathology, such as ageing-related diseases, malignant transformation, atherosclerosis, neurodegenerative diseases, obesity, and diabetes. Our research has been focused on the crosstalk between these small molecules and macromolecules, trying to explore the relationship between protein function and cellular redox status. We aim to explore the relationship between protein function and cellular redox status, which is one fundamental question in Redox Biology. To reach this goal, we are going to demonstrate cellular Redox network, draw cellular Redox map and illustrate Redox response including oxidative stress and reductive stress. Based on it, try to find out effective approach, such as Chinese medicine, to maintain cellular redox homeostasis and apply for healthy aging and treatment for redox related disease.
Publications
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3. Gao, L., Zhang, Y.Y., Wang Y., Qiao X.H., Zi, J., Chen, C.* & Wan, Y.* (2016) . Reduction of PCN biosynthesis by NO in Pseudomonas aeruginosa. Redox Bio. 8, 252–258.
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2. Zhang, H., Yang, J., Si, W., Gong, W., Chen, C.* & Perrett, S.* (2016). Glutathionylation of DnaK provides a link between oxidative stress and the heat shock response. J. Biol. Chem. 291, 6967-6981.
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1. Meng, J., Lv, Z.Y., Qiao, X.H., Li, X.P., Li, Y.Z. & Chen, C.* (2017). The decay of Redox-stress Adaptive Capacity is a substantive characteristic of aging: revising the redox theory of aging. Redox Bio.11,365-374.
