Dacheng Wang

Biography

1958-1963 University of Science and Technology of China, B. Sc. in Biophysics 1963-1986　Primary Investigator, Assistant Investigator, Associate Investigator, Institute of Biophysics, Chinese Academy of Sciences 1982-1984　Alexander von Humboldt Research Fellow, Max-Plank Institute of Biochemistry, Department of Macromolecular Structure, Germany 1988 Wellcome Research Fellow, Department of Chemistry, York Univeristy, Great Britain 2005 Academician, Chinese Academy of Sciences 1997-present　Editor-in-Chief，Progress in Biochemistry and Biophysics 2008-present　Editor-in-Chief，Science in China – Life Sciences Past positions: Vice Director of the Institute of Biophysics; Director of the Center for the Molecular Biology, Institute of Biophysics; Vice Chairman of the Crystallographic Society of China; Vice Chairman of the Biophysical Society of China. 1958-1963 University of Science and Technology of China, B. Sc. in Biophysics 1963-1986　Primary Investigator, Assistant Investigator, Associate Investigator, Institute of Biophysics, Chinese Academy of Sciences 1982-1984　Alexander von Humboldt Research Fellow, Max-Plank Institute of Biochemistry, Department of Macromolecular Structure, Germany 1988 Wellcome Research Fellow, Department of Chemistry, York Univeristy, Great Britain 2005 Academician, Chinese Academy of Sciences 1997-present　Editor-in-Chief，Progress in Biochemistry and Biophysics 2008-present　Editor-in-Chief，Science in China – Life Sciences Past positions: Vice Director of the Institute of Biophysics; Director of the Center for the Molecular Biology, Institute of Biophysics; Vice Chairman of the Crystallographic Society of China; Vice Chairman of the Biophysical Society of China.

Research Interest

The research of our group has focused on the three dimensional structures of proteins and their structure-function relationships and the protein engineering of for a rather long time. Previous research subjects included protein hormones, polypeptide neuron toxins, and some defense proteins with antifungal, antiviral, and antitumor activities. It has participated in the structural analysis of pig insulin, the first proteins to be studied by crystallography in China. The major research achivements were received two Second Prizes of the National Natural Science Award of China and one First Prize of the Science Progress Award of the Chinese Academy of Sciences. The current research interest of the group is on the structural biology of pathogenesis, especially the structure-function relationships and molecular mechanisms of proteins involved in diseases caused by both exogenous factors (such as infections by pathogenic microbes) and endogenous factors (such as naturally occurred mutations). The studies are essential for illustrating the mechanisms of the onset and defense of relative diseases and providing accurate knowledge and new idea to disease prevention and drug design