Dr. Ke-qian Yang
Professor
Institute of Microbiology
Chinese Academy of Sciences
China
Biography
1987/1993 Ph.D., Under Professor Leo C. Vining Department of Biology Dalhousie University 1981/1985 B.Sc. (Honors), Marine Biology Department of Marine Biology Qingdao University of Oceanography Qingdao, P.R. China 2003/present Professor Center for Metabolic Engineering, Institute of Microbiology IMCAS 2001/2003 Associate Professor, IMCAS 1999/2000 Senior Investigator, FermaLogic Inc. Chicago, USA 1998/1999 Post Doctoral Fellow, with Julian Davies Department of Microbiology & Immunology The University of British Columbia 1993/1997 Post Doctoral Fellow, with Leo C. Vining Department of Biology Dalhousie University Halifax, Nova Scotia Canada
Research Interest
Our interests are mainly centered around bacterial physiology and metabolism. We hope to use our knowledge of bacterial physiology in the development of microorganisms for biotransformation and biocatalysis applications. The group is currently actively working on the identification and characterization of novel enzymatic reactions and metabolic pathways, and their improvement and application. We try to study bacterial functions at an integrated level by analyses of protein interaction and omic data.
Publications
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[3] Weishan Wang, Xiao Li, Juan Wang, Sihai Xiang, Xiaozhou Feng, Keqian Yang*.An Engineered Strong Promoter for Streptomycetes.Applied and Environmental Microbiology,2013, 79(14):4484-4492.
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[2] Pauli Kallio, Pekka Patrikainen, Georgiy A. Belogurov, Pekka Mäntsälä, Keqian Yang, Jarmo Niemi, Mikko Metsä-Ketelä*.Tracing the Evolution of Angucyclinone Monooxygenases: Structural Determinants for C-12b Hydroxylation and Substrate Inhibition in PgaE.Biochemistry, 2013, 52(26):4507-4516.
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[1] Dekun Guo, Youbao Zhao, Keqian Yang*. Coordination of Glycerol Utilization and Clavulanic Acid Biosynthesis to Improve Clavulanic Acid Production in Streptomyces Clavuligerus. Science China Life Sciences, 2013, 56(7):591–600.
