Hongyu Deng
Professor
Institute of Biophysics
Chinese Academy of Sciences
China
Biography
1992-1997 Ph. D., University of Rochester, USA 1998-2002 Postdoctoral fellow, Albert Einstein College of Medicine & University of California at Los Angeles 2002-2004 Assistant Researcher & Assistant Professor, University of California at Los Angeles 2004-present Professor (Principle Investigator), Institute of Biophysics, Chinese Academy of Sciences Dr. Deng has spent much of her career studying viruses that are causative agents for tumors. Her main research interests are to investigate the replication mechanisms of viruses and virus-host interactions, so as to gain insights into viral pathogenesis and to develop better therapeutics and diagnosis. Her current work are summarized as follows: 1) to study the mechanisms governing transcriptional regulation, genome replication, and virion morphogenesis and egress of tumor-associated herpesviruses; 2) to investigate the interactions between tumor-associated herpesviruses and the host innate and adaptive immune systems, both in vitro and in vivo; 3) to develop and test novel gene delivery vectors based on a murine herpesvirus; 4) to investigate the underlying mechanisms for viral hepatitis
Research Interest
Her main research interests are to investigate the replication mechanisms of viruses and virus-host interactions, so as to gain insights into viral pathogenesis and to develop better therapeutics and diagnosis
Publications
-
Qi J, Han C, Gong D, Liu P, Zhou S, and Deng H*. Murine gammaherpesvirus 68 ORF48 is an RTA responsive gene product and functions in both viral lytic replication and latency during in vivo infection. J Virol. 2015 Jun 1;89(11):5788-800. doi:10.1128/JVI.00406-15. Epub 2015 Mar 11. JVI Spotlight.
-
Chen Y, He L, Shi X, Chen J, Zhong J, Chen X, Cheng G*, Deng H*. The hepatitis C virus protein NS3 suppresses TNF-a–stimulated activation of NF-kB by targeting LUBAC. Sci Signal. 2015 Nov 17;8(403): ra118. doi: 10.1126/scisignal.aab2159.
-
Jia X, Shen S, Lv Y, Zhang Z, Guo H, Deng H*. Tegument Protein ORF45 Plays an Essential Role in Virion Morphogenesis of Murine Gammaherpesvirus 68. J Virol. 2016 Jul 27;90(16):7587-92. doi: 10.1128/JVI.03231-15. Print 2016 Aug 15.
