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Bioinformatics & Systems Biology Experts

Jianyuan Sun


Institute of Biophysics
Chinese Academy of Sciences
China

Biography

Dr. Sun completed his Ph.D and became a faculty member in the Department of Biology at East China Normal University in 1993. In 1997, He did his postdoctoral fellowship with Dr. Wolf Almers at the Max Planck Institute for Medicine Research in Heidelberg, Germany. During 1999-2002, he worked as a research associate in Dr.Ling-Gang Wu's lab at Washington University in St. Louis. In 2002, he was appointed as an assistant professor(research track) in the Department of Neuroscience, UT Southwestern Medical Center, Dallas. He joined the Institute of Biophysics, Chinese Academy of Sciences, as a principal investigator in 2008.Dr. Sun completed his Ph.D and became a faculty member in the Department of Biology at East China Normal University in 1993. In 1997, He did his postdoctoral fellowship with Dr. Wolf Almers at the Max Planck Institute for Medicine Research in Heidelberg, Germany. During 1999-2002, he worked as a research associate in Dr.Ling-Gang Wu's lab at Washington University in St. Louis. In 2002, he was appointed as an assistant professor(research track) in the Department of Neuroscience, UT Southwestern Medical Center, Dallas. He joined the Institute of Biophysics, Chinese Academy of Sciences, as a principal investigator in 2008.

Research Interest

Dr. Sun’s research interests are focused on the molecular and cellular mechanism of synaptic vesicle release. His laboratory uses an interdisciplinary approach with combination of biophysics and molecular biology to explore the mechanism that the presynaptic secretory machinery achieves the precise neurotransmitter release. He is particularly interested in 1). The molecular mechanism that determines the coupling between calcium channels and synaptic vesicles and how this spatial organization governs vesicle release probability, vesicle release kinetics and synaptic plasticity. 2). The signaling mechanisms that link different modes of synaptic transmitter release to neuronal coding.

Publications

  • Sun J-Y*, Pang ZP, Qin D-Q, Fahim A, Adachi R, and Südhof TC*, A Dual-Ca2+-Sensor Model for Neurotransmitter Release in a central Synapse. NATURE , 450(7170):676-683, 2007

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