Jie Feng
Professor
Institute of Microbiology
Chinese Academy of Sciences
China
Biography
Education 2002-2006 Ph.D (IMCAS), Identfication of a novel maleylpyruvate isomerase that needs mycothiol as cofactor and links mycothiol biosynthesis and gentisate assimilation in Corynebacterium glutamicum. Professional Experience 2009-Present Principal Investigator, Associate Professor, Institute of Microbiology, Chinese Academy of Sciences (IMCAS) 2006-2009 Postdoc at Infectious Disease Research Center, University, Canada, Genome sequencing and proteomic and transcriptomic analysis revealed novel mechanism of linezolid resistance in Streptococcus pneumonia, supported by CIHR grant
Research Interest
Our group is committed to investigating the novel acquired and intrinsic resistance genes in bacterial pathogens, as well as in environmental bacteria. We are also trying to explore the mobility of novel mobile elements, to uncover the mechanism of dissemination of resistance genes. We believe that our studies will substantially contribute to understanding of the evolution and epidemiology of resistance. The researches in our group are currently focused on the development of resistance, including: 1) Acquired resistance, we identified a number of novel acquired resistance genes and mobile elements unraveling the way that bacteria develop resistance; 2）Intrinsic resistance, we characterize the novel intrinsic resistance genes in Bacillus and Acinetobacter, and demonstrated that the intrinsic resistance genes can be the origin of acquired resistance genes. 3) Diagnosis of phenotype and genotype of resistant bacteria
Publications
-
Leclercq Sebastien Olivier, Wang Chao, Sui Zhihai, Wu Hai, Zhu Baoli, Deng Ye, Feng Jie*.A multi-player game: Clostridium, Acinetobacter, and Pseudomonas species drive the antibiotic-resistance gene persistence in manured soils.Environ Microbiol. 2016, 18(10):3494-3508.
-
Zhang Gang, Leclercq Sebastien Olivier, Tian Jingjing, Wang Chao, Yahara Koji, Ai Guomin, Liu Shuangjiang, Feng Jie*. A new subclass of intrinsic aminoglycoside nucleotidyltransferases, ANT(3")-II, is horizontally transferred among Acinetobacter spp. by homologous recombination. PLoS Genet. 2017, 13(2)
-
Xu Yixiang, Wang Chao, Zhang Gang, Tian Jingjing, Liu Ying, Shen Xihui, Feng Jie*. ISCR2 is associated with the dissemination of multiple resistance genes among Vibrio spp. and Pseudoalteromonas spp. isolated from farmed fish. Arch Microbiol. 2017 Mar 29. doi: 10.1007/s00203-017-1365-2.
