Jinhui Wang

Biography

1992, Ph.D. Shanghai Institute of Physiology, CAS; 1992-1994, Postdoctoral fellow at State University of New York, USA; 1995-1999, Research Scientist at the University of Texas Houston, USA; 1999.8-2004.5, Assistant professor (tenure-track) at the University of Kansas, USA; 2003-12 to present, Professor at the Institute of Biophysics, CAS  1992, Ph.D. Shanghai Institute of Physiology, CAS; 1992-1994, Postdoctoral fellow at State University of New York, USA; 1995-1999, Research Scientist at the University of Texas Houston, USA; 1999.8-2004.5, Assistant professor (tenure-track) at the University of Kansas, USA; 2003-12 to present, Professor at the Institute of Biophysics, CAS 

Research Interest

Research focuses in my lab include molecular and cellular mechanisms underlying the precise analysis and computation of neural signals at the different cellular compartments (the neurons, synapses and networks), the functional development of inhibitory interneurons, as well as the genetics and neurobiology of functional disorders and ischemic stroke in the brain. Multiple disciplinary approaches are used to address these critical issues such as cellular electrophysiology with patch-clamp in vitro/vivo, cellular imaging by two-photon laser scanning microscopy in vivo, intracellular microinjection to anipulate biochemical reactions or gene expressions, gene analysis in single living neurons, lentivirus and AAV-mediated gene transfer in specific-type of neurons to knock-down or over-express genes, immunohistochemistry, behavioral tasks and math-physical modeling. Our major findings are listed in followings. 1) Homeostasis established through coordinating the function of subcellular compartments improves neuronal encoding. 2) The gain and fidelity of transmission patterns at unitary synapses improve neuronal encoding. 3) VGSC-mediated intrinsic properties navigate the spike encoding of cortical neurons. 4) An increase of intracellular Ca2+ during ischemia deteriorates the signal encoding of GABAergic neurons.