Jizhong Lou

Biography

1990–1994: BS in physics, Jilin University. 1994–1997: MS in physics, Peking University. 1997–2000: Ph.D in physics, Institute of theoretical physics, CAS. 2000–2001: Postdoctoral Fellow, University of Nevada, Las Vegas. 2001–2005: Postdoctoral Fellow, Georgia Institute of Technology. 2005–2009: Research Scientist, Georgia Institute of Technology. 2009 - : Principal Investigator, Institute of Biophysics, CAS 1990–1994: BS in physics, Jilin University. 1994–1997: MS in physics, Peking University. 1997–2000: Ph.D in physics, Institute of theoretical physics, CAS. 2000–2001: Postdoctoral Fellow, University of Nevada, Las Vegas. 2001–2005: Postdoctoral Fellow, Georgia Institute of Technology. 2005–2009: Research Scientist, Georgia Institute of Technology. 2009 - : Principal Investigator, Institute of Biophysics, CAS

Research Interest

We combine single-molecule biophysics and molecular dynamics simulations to study the dynamical recognition between Biomacromolecules. Currently our researches focus on two aspects. Firstly, the molecular mechanisms and mechanical regulations of signal transduction across the cell membranes. Using T-cell as a model system, we studied 1) the molecular mechanisms of antigen recognition of T-cell receptors and the resulting signal transduction and 2) how PD1 recognize its ligands; Secondly, we studied the target DNA recognition mechanisms of CRISPR-CAS systems.