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Bioinformatics & Systems Biology Experts

Kang Shen


Institute of Biophysics
Chinese Academy of Sciences
China

Biography

1999-2003  Postdoctoral Fellow, University of California San Francisco, San Francisco, Advisor: Cori Bargmann 1994-1999  Ph.D., Cell Biology, Duke University Medical Center; Advisor: Tobias Meyer 1989-1994  Bachelor of Medicine, Tongji Medical University, Wuhan, Hubei, China Professional Experience: 2013-present  Professor with tenure at Stanford University, Department of Biology, Department of Pathology 2012-present  Principle Investigator, Institute of Biophysics, Chinese Academy of Sciences 2009-2013  Associate Professor with tenure at Stanford University, Department of Biology, Department of Pathology 2008-present  Investigator, Howard Hughes Medical Institute 2008-2009  Assistant Professor at Stanford University, Department of Pathology 2003-2009  Assistant Professor at Stanford University, Department of Biology 1999-2003  Postdoctoral Fellow, University of California San Francisco, San Francisco, Advisor: Cori Bargmann 1994-1999  Ph.D., Cell Biology, Duke University Medical Center; Advisor: Tobias Meyer 1989-1994  Bachelor of Medicine, Tongji Medical University, Wuhan, Hubei, China Professional Experience: 2013-present  Professor with tenure at Stanford University, Department of Biology, Department of Pathology 2012-present  Principle Investigator, Institute of Biophysics, Chinese Academy of Sciences 2009-2013  Associate Professor with tenure at Stanford University, Department of Biology, Department of Pathology 2008-present  Investigator, Howard Hughes Medical Institute 2008-2009  Assistant Professor at Stanford University, Department of Pathology 2003-2009  Assistant Professor at Stanford University, Department of Biology

Research Interest

We are interested in neuron development. Dendrites play an important role in the formation of neural circuits and information exchange among neurons. Many neuronal diseases are associated with the malfunction of dendrites, such as Schizophrenia, autism, Rett syndrome, Down's syndrome et al. The normal function of dendrite is essential for neuron system. While the mechanism of dendrite morphogenesis is not very clear. Here we use PVD neuron, which has many complex branches as the mammals, as the model system to study dendrite morphogenesis and maintenance. We will use genetic screen, molecular biology, cell biology, biochemistry assays to study the mechanism of these two and new genes screened in PVD dendrite development. This study might shed light on the associated dendrite diseases study of mammals.

Publications

  • Chia, PH, Chen B., Li P., Rosen MK, and Shen K.*, Local F-actin Network Links Synapse Formation and Axon Branching., Cell, 2014 Jan 16, Volume 156, Issue 1-2, p.208-20. (*Correspondence author)

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