Mi Shuangli
Professor
Beijing Institute of Genomics
Chinese Academy of Sciences
China
Biography
2009.8 - present Professor, Beijing Institute of Genomics, Chinese Academy of Sciences, China 2008.7-2009.8 Postdoctoral Scholar/Research Associate, Pharmacogenetics Anticancer Agents Research Group, University of Chicago, USA 2005.7 - 2008.7 Postdoctoral Fellow, Department of Medicine, Section of Hematology/Oncology, University of Chicago, USA 1999 - 2005 Ph.D, College of Life Sciences, Peking University, Beijing, China
Research Interest
MicroRNA is a class of small non-protein-coding RNAs which has being a research hotspot in the biological fields because of its universality, complexity and significance, especially its key role in the cancerogenesis and development. Our main work is to study the regulation mechanism of microRNA expression in different type of leukemia. The methylation status, CNV and the histone modification in the gene regulatory region were analyzed by microarray and the high-throughput DNA/RNA sequencing technology. Simultaneously, we employed hemopoietic stem cell, RNA-interference, and the transgenic mice model to study the function of microRNA and its target genes in the development of leukemia and the differentiation of the hematopoiesis. Pharmacogenetics and Pharmacogenomics lay the foundation for individualized medicine, which integrate genetics, genomics, bioinformatics, clinical medicine and the pharmacology. Our work is to determine the association of gene polymorphism, differential gene expression and individual drug response or drug toxicity of different anticancer agents by genome-wide association study, which provided the evidence for clinical trials in translational medicine. 1. The role of non-coding RNAs (microRNAs and long non-coding RNAs) in leukemogenesis, tumor development and drug resistance. 2. The sorting mechanism of tumor exosomal RNAs and novel biomarker identification for precision medicine. 3. The regulation role of intestinal microbiota in metabolic diseases.
Publications
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Zhu X, He F, Zeng H, Ling S, Chen A, Wang Y, Yan X, Wei W, Pang Y, Cheng H, Hua C, Zhang Y, Yang X, Lu X, Cao L, Hao L, Dong L, Zou W, Wu J, Li X, Zheng S, Yan J, Zhang L, Mi S, Wang X, Zhang L, Zou Y, Chen Y, Geng Z,Wang J, Zhou J, Liu X, Wang J, Yuan W, Huang G, Cheng T, Wang QF. Identification of functional cooperative mutations of SETD2 in human acute leukemia. Nat Genet. 2014 Mar; 46(3):287-93
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Zhang J, Li S, Li L, Li M, Guo C, Yao J, Mi SL*. Exosomal MicroRNA: Trafficking, sorting and function. Genomics Proteomics Bioinformatics. 2015, 13(1):17-24.
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Jerome Mertens, Qiu-Wen Wang, et al. Shuangli Mi. Differential responses to lithium in hyperexcitable neurons from patients with bipolar disorder. Nature. 527,95-9(2015).
