Institute of Biophysics
Chinese Academy of Sciences
1994-1998, B.S. Peking University 1998-2003, Ph.D. Chinese Academy of Medical Science & Peking Union Medical College 2004-2008, Postdoctoral Research Associate, University of Chicago 2009.1-2009.10, Research Assistant Professor, University of Chicago 2009.10, Professor, Institute of Biophysics, CAS, supported by CAS Hundred Talent Program
Development, homeostasis, remodeling and function of lymphoid organs Primary lymphoid organs are the sites for lymphocytes development and education. Secondary lymphoid organs and tissues are the sites where immune responses are initiated; they also function as filters to clear and concentrate particulate matter from the blood or lymph. Tertiary lmyphoid tissues develop during persistent infection/inflammation, indicating an important role in the development of chronic diseases. Lymphoid stroma plays critical roles in the development and function of immune cells. We are devoted to revealing the molecular and cellular mechanisms underlying lymphoid stroma development, homeostasis and remodeling under physiological and pathological changes; further more, we are aiming to reveal the biological function and consequence of lymphoid stroma development, homeostasis and remodeling. 1. Thymic epithelial cell development, homeostasis and crosstalk with thymocytes for T cell development. 2. Thymic injury and regeneration. 3. Lymph node development, neogenesis and remodeling. 4. Lymphangiogenesis and angiogenesis. 5. Dendritic cell migration and function.
Shi, Y., Wu, W., Chai, Q., Li, Q., Hou, Y., Xia, H., Ren, B., Xu, H., Guo, X., Jin, C., Lv, M., Wang, Z., Fu, Y., and Zhu, M. LTbetaR controls thymic portal endothelial cells for hematopoietic progenitor cell homing and T cell regeneration. Nature Communications 7, 12369. (2016)