Prof. Yihua Chen
Professor
Institute of Microbiology
Chinese Academy of Sciences
China
Biography
Dr. Chen was born in a mountain village in Shandong Province, China. He graduated from Nanjing Agricultural University in 1998 and earned his Ph. D. degree in the Institute of Microbiology, CAS in 2005. After five years postdoctoral training in Prof. Ben Shen’s Lab in University of Wisconsin-Madison, he joined the Institute of Microbiology, CAS in 2011.
Research Interest
(1) Biosynthetic mechanisms of microbial natural products, including anti-infection drugs, agricultural antibiotics and antitumor agents. 　　(2) Mining of specific type of natural products from actinomycetes genomes and develop high-throughput genome mining strategy. 　　(3) Investigation on actinomycetes signal molecules. 　　(4) Synthetic biological investigations on microbial natural products
Publications
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　　3. Yihua Chen, Min Yin, Geoff P. Horsman, and Ben Shen. (2011) Improvement of the Enediyne Antitumor Antibiotic C-1027 Production by Manipulating Its Biosynthetic Pathway Regulation in Streptomyces globisporus. Journal of Natural Products 74:420-424.
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　　2. Jine Li, Zhengyan Guo, Wei Huang, Xiangxi Meng, Guomin Ai, Gongli Tang and Yihua Chen. (2013) Mining of a streptothricin gene cluster from Streptomyces sp. TP-A0356 genome via heterologous expression. Sci China Life Sci. 56:619-627.
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　　1. Haiyan Chen, Ning Liu, Ying Huang, Yihua Chen. (2014) Isolation of an anthrabenzoxocinone 1.264-C from Streptomyces sp. FXJ1.264 and absolute configuration determination of the anthrabenzoxocinones. Tetrahedron: Asymmetry. 25:113-116.
