Sarah Perrett

Biography

1992　　　   BA in Chemistry, University of Cambridge, UK 1997　　　   PhD in Protein Chemistry, University of Cambridge 1996-1997　 Post-Doctoral Research Associate, University of Cambridge 1997-2000　 College Research Fellow, University of Cambridge 1999-2000　 Chinese language study, National University of Singapore 2000-2003　 1851 & Royal Society Research Fellow, CAS Institute of Biophysics, Beijing 2003-present Principal Investigator, CAS Institute of Biophysics 1992　　　   BA in Chemistry, University of Cambridge, UK 1997　　　   PhD in Protein Chemistry, University of Cambridge 1996-1997　 Post-Doctoral Research Associate, University of Cambridge 1997-2000　 College Research Fellow, University of Cambridge 1999-2000　 Chinese language study, National University of Singapore 2000-2003　 1851 & Royal Society Research Fellow, CAS Institute of Biophysics, Beijing 2003-present Principal Investigator, CAS Institute of Biophysics

Research Interest

1. Folding and Assembly of Functional Amyloids We are studying the detailed mechanism of fibril assembly for functional amyloids, such as the yeast prion protein Ure2 and the bacterial Chaplin proteins, in order to understand how biological systems regulate protein folding and misfolding. 2. Protein Folding, Post-Translational Modification & Quality Control We are studying the detailed mechanisms by which molecular chaperones control protein folding and misfolding. In particular, we are examining the role of post-translational modification of the molecular chaperone Hsp70 in regulating its structure and function. 3. Biological Properties of Nanomaterials We are studying how the unique properties of amyloid can be exploited in the design of novel nanomaterials. Conversely, we are examining how nanomaterials that are widely used in medical applications interact with amyloidogenic proteins and affect their folding and misfolding.