Shaohui Huang
Professor
Institute of Biophysics
Chinese Academy of Sciences
China
Biography
1988-1991 Undergraduate study in Biochemistry, Sun Yat-sen University, Guangzhou, China 1991-1993 B.S. in Biochemistry, Department of Molecular Biosciences, the University of Kansas, Lawrence, Kansas 1993 -1998 Ph.D. in Biochemistry, Molecular & Cell Biology, Department of Molecular Biosciences， the University of Kansas, Lawrence, Kansas 1998-2002 Postdoctor, School of Applied and Engineering Physics, Cornell University, Ithaca, New York 2002-2009 Research Assistant Professor, Program in Molecular Medicine, the University of Massachusetts Medical School, Worcester, Massachusetts 2009-2013 Investigator, Institute for Environmental Medicine (IFEM), the University of Pennsylvania School of Medicine, Philadelphia, PA 2009-2013 Director, IFEM Pulmonary Imaging and Morphology Core, the University of Pennsylvania School of Medicine, Philadelphia, PA 2010-2013 Research Assistant Professor, Department of Physiology, the University of Pennsylvania, Philadelphia, PA 2013-present Principal Investigator，Center for Interdisciplinary Study, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China
Research Interest
1) Instrument development : our team developed a portable, ultrasensitive molecular analyzer based on fluorescence correlation spectroscopy principles. We have also built an advanced single-molecule research platform integrating multiparameter fluorescence detection and atomic force microscopy techniques. 2) Molecular mechanism of organelle biogenesis: we are investigating the molecular mechanism of giant lamellar bodies (GLBs) in the alveolar type II pneumocyte. Lung fibrosis related to GLB is the fatal cause of Hermansky-Pudlak Syndrome patients.
Publications
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3. Yu, M., Huang, S., Yu, K.J., & Clyne, A.M. (2012). Dextran and polymer polyethylene glycol (PEG) coating reduce both 5 and 30 nm iron oxide nanoparticle cytotoxicity in 2D and 3D cell culture. International Journal of Molecular Sciences, 13(5), 5554-5570.
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2. Rahaman, H., Zhou, S., Dodia, C., Feinstein, S.I., Huang. S., Speicher, D.W. & Fisher, A.B. (2012). Increased phospholipase A(2) activity with phosphorylation of peroxiredoxin 6 requires a conformational change in the protein. Biochemistry, 51(27), 5521-5530.
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1. Roszell, B.R., Tao, J.Q., Yu, K.J., Gao, L., Huang, S., Ning, Y., Feinstein, S.I., Vite, C.H., & Bates, S.R. (2013). Pulmonary Abnormalities in Animal Models Due to Niemann-Pick Type C1 (NPC1) or C2 (NPC2) Disease. PLoS One, 8(7):e67084.
