Sheng Wu
Professor
Institute of Microbiology
Chinese Academy of Sciences
China
Biography
Education Experience B.S. 1998 Microbiology & Pharmacology, Shenyang Pharmaceutical University M.S. 2001 Biochemistry & Pharmacology , Shenyang Pharmaceutical University Ph.D. 2006 Biochemistry & Molecular biology, Institute of Microbiology, Chinese Academy of Sciences (IMCAS) Professional Experience 2006.9-2009.9 Postdoctoral Fellow, In Prof. Dr. Manfred T Reetz’s Lab, Max-Planck-Institut für Kohlenforschung, Germany; 2009.10-2009.12 Assistant Professor, Institute of Biophysics, CAS 2009.12-present Associate Professor, Principal Investigator, IMCAS
Research Interest
Synthesis of chiral drugs, agrochemicals and the intermediates by biotransformation and biocatalysis. Protein engineering (rational design and directed evolution). Discovering novel enzymes by active screening or genome mining; enzyme molecular recognition and catalytic mechanism. Developing the novel chiral biomaterials.
Publications
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Reetz MT*, Wu S. Greatly reduced amino acid alphabets in directed evolution: making the right choice for saturation mutagenesis at homologous enzyme positions. Chem Commun. 2008, 43: 5499-5501.
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Reetz MT*, Wu S. Laboratory evolution of a robust and enantioselective Baeyer-Villiger monooxygenase for asymmetric catalysis (Article). J Am Chem Soc. 2009, 131: 15424–15432.
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Wu S, Acevedo-Cox JP, Reetz MT*. Induced allosteric communication in the directed evolution of an enantioselective Baeyer-Villiger monooxygenase, Proc Natl Acad Sci USA. 2010, 107：2775-2780
