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Microbiology Experts

Tien Po

Professor
Institute of Microbiology
Chinese Academy of Sciences
China

Biography

Prof. TIEN received funding on a series of projects related to molecular virology and molecular immunology including national projects, such as 973 projects, 863 projects, Gongguan projects etc. He also tasked international collaborative projects and joint projects with industry. He published more than 100 research papers on international SCI journals and published 8 books. He also applied for several patents, and five China patents and one US patent of them were granted. He won the Natural Science and Science & Technology Advancement Awards from China and from the Chinese Academy of Sciences. He has also received the HLHL PRIZE of Science & Technology Advancement in 1999. And he was selected as an Asian famous scientist by the Asia-Pacific Biotech News in 1999. He was recommended for full membership in the America Society for Virology. He is a life member of the Indian Virological Society.    

Research Interest

The group is mainly interested in molecular mechanism of HBV T-cell immunity and enveloped virus-cell fusion. In early research, his group was mainly focused on plant viruses and subvirus. The group is the first one in the world to have successfully applied viral satellite RNA as biological control agents to prevent plant diseases in the field. And their work provided the first  example of ribozyme that can completely inhibit a viroid pathogen in transgenic potato plants. In recent years, the laboratory is mainly interested in molecular mechanism of HBV T-cell immunity and enveloped virus-cell fusion.  

Publications

  • [3] Su Yan,Po Tien*, Analysis of a point mutation of H5N1 avian influenza virus hemagglutinin in relation to virus entry into live mammalian cells, Archives of Virology, 153(12): 2253-61, 2008.

  • [2] Pang W, Wang RR, Yang LM, Liu CM, Tien* P, Zheng* YT. Recombinant protein of heptad-repeat HR212, a stable fusion inhibitor with potent anti-HIV action in vitro. Virology, 377: 80-87, 2008.

  • [1] Yong Chen, Feng Gao, Fuliang Chu, Hao Peng, Lili Zong, Yiwei Liu, Po Tien, George F. Gao. Crystal structure of myeloid cell activating receptor leukocyte lg-like receptor A2 (LILRA2/IL T1/LIR-7) domain swapped dimer: molecular basis for its non-binding to MHC complexes. J. Mol. Biol., 2009.

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