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Bioinformatics & Systems Biology Experts

Yingfang Liu


Institute of Biophysics
Chinese Academy of Sciences
China

Biography

1993-1999 Graduate student, Dept. of Plant Molecular Biology, Peking University, P.R. China. 1999- 2005 Postdoctoral Associate, National Jewish Medical and Research Center, W. M. Keck Structural Biology Laboratory, Cold Spring Harbor Laboratory and Duke University Medical Center. 2005-present: Principal Investigator, Institute of Biophysics, CAS. First Prize, Beijing Science & Technology Award (2010) 1993-1999 Graduate student, Dept. of Plant Molecular Biology, Peking University, P.R. China. 1999- 2005 Postdoctoral Associate, National Jewish Medical and Research Center, W. M. Keck Structural Biology Laboratory, Cold Spring Harbor Laboratory and Duke University Medical Center. 2005-present: Principal Investigator, Institute of Biophysics, CAS. First Prize, Beijing Science & Technology Award (2010)

Research Interest

Dr. Yingfang Liu obtained his doctor degree on Plant Science in Peking University, 1999. In his postdoctoral training period in USA, he was mainly working on structure biology and engaged in structural and functional studies of some very important proteins, such as SarA, SarR, TALL-1 and its receptors and had got plenty of results. Currently, Liu’s lab is mainly working on structural biology studies of some proteins related to cancer, virus, replication and apoptosis. The research interest is as following: 1. Replication of some negative stranded RNA viruses and the host innate immune responses upon virus infection. Especially, we are trying to study some viral proteins involved in viral genome replication and the host proteins that are induced by interferon upon viral infection. 2. Eukaryotic cell apoptosis and replication. Our long term goal is to study some proteins involved in cancer generation and development, in order to develop some new approaches to against cancer.

Publications

  • Yang Z. L., Liang H. H., Li Y., Qian Q., Ye W., Fleming J., Shu H. B. and Liu Y. F*. (2012). Crystal structure of ISG54 reveals a novel RNA binding structure and potential functional mechanisms. Cell Res. 22:1328-1338.

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