Institute of Biophysics
Chinese Academy of Sciences
1992-1999 Hunan Normal University, B.Sc & M.Sc in Biochemistry and Molecular Biology 1999-2003 Shanghai Institute of Biochemistry and Cell biology, Chinese Academy of Sciences, Ph.D. in Biochemistry and Molecular Biology 2003-2011 National Institutes of Health, National Cancer Institute, Visiting / Research Fellow 2011 - Principal Investigator, National Laboratory of Biomacromolecules. Institute of Biophysics, Chinese Academy of Sciences
Epigenetic regulation controls dynamic changes in chromatin structure to modulate gene expression. Structural alternation of chromatin is one of the major epigenetic mechanisms of genome regulation in eukaryotes. Histone chaperones refer to a diverse group of molecules which directly interact with histones. They play an important role in epigenetic regulation by stimulating multiple reactions including histone modification, selection, transfer, storage and displacement. Our lab is interested in how histone chaperons, the key players in histone metabolism, regulate the changes of chromatin structure. Our interests are mainly focused on structure and dynamics of nucleosome or nucleosome sub-complexes with vital biological function. The long-term goal of my research is to understand the epigenetic mechanism within the context of highly compacted chromatin. Our current study include (1) mechanism for recognition of histone by histone chaperon, (2) chromatin remodeling process in which histone chaperone involves, and, (3) dynamics of histone or nucleosome and their biological impact. Nuclear Magnetic Resonance (NMR) spectroscopy has demonstrated power and advantage in studying protein solution structure, protein-protein interaction and dynamics. We will apply modern NMR spectroscopy, X-ray crystallography techniques as well as a wide array of other approaches including biochemistry, biophysics, and yeast genetics to address above questions.
Liang X, Shan S, Pan L, Zhao J,Ranjan A, Wang F, Zhang Z, Huang Y, Feng H, Wei D, Huang L, Liu X, Zhong Q, Lou J, Li G, Wu C, Zhou Z. (2016) Structural basis of H2A.Z recognition by SRCAP chromatin-remodeling subunit YL1. Nat.Struct. Mol. Biol. 23(4):317-23.