Yu Dequan

Biography

Prof. Yu has been working in the study of natural products chemistry for over 40 years and has made outstanding accomplishments. He is one of the chief scientists of the key projects of medicinal chemistry. He has carried out the study on chemical constituents of over 50 Chinese herbal Medicines and found about 200 new compounds, of which the structures have been determined. Prof. Yu has participated in taking charge of the study on a National key Project " Artificial Musk" and to be responsible for the overall plan design, composition principles, production technology, quality control as well as the solution of problems in production . The project of "Artificial Musk" has been awarded the first Grade Prize for the Progress in Science and Technology by the National Management Bureau of Chinese Traditional Medicine.Prof. Yu had carried out studies on the isolation, structural elucidation, structural modification and synthesis of many natural products, including the purification and transformation of Changshan alkaloids dichroine A and B; the structure determination of hydroginkgolic acid; the structure elucidation and synthesis of gentianidine; and the search for antivirotic constitutes from Lian-Qiao (Forsythia auspensa) and Da-Qing-Ye (Isatis tinctoria). He has carried out studies on the antimalaria constituents from Chinese herbal medicine; structure determination of Ying-Zaosu A and B, two active antimalaria compounds from Artabotrys uncinatus. He has also carried out studies on the chemical constituents from Rhododendron dauricum; diterpene alkaloids from Spiraea japonica; active constituents from Polygonatum sibiricum, Triterygium wilfordii, Goanoderma lucidum and etc. In addition, Prof. Yu has carried out the study to solve the problems in the production technology of reserpine and has gained important results. Recently, Prof. Yu has studied on the chemical constituents from Chinese traditional medicine. He has found an immunosuppressive compound from Chinese traditional medicine Gao-Ben and has got Japan patent. This project has been awarded a Second Grade Prize for Progress in Science and Technology by Ministry of Public Health. In study on the antitumor constituents from Annonaceac plant, Prof. Yu has isolated and identified over 50 new active antitumor compounds, one of them showed strong antitumor activity in vitro and in vivo and having low toxicity. Prof. Yu has carried out the structural elucidation and the total synthesis of this compound. This project has also been awarded a Second Grade Prize for the Progress of Science and Technology by Ministry of Public Health. Prof. Yu has been awarded the Qui-Shi Science and Technology Prize (2001)Prof. Yu has published over 280 papers and has got 10 patents.

Research Interest

Pharma