Weidong Le
Professor,
Department of Neurology
Dalian Medical University
China
Biography
19891990: Postdoctoral, Department of Neurology, Baylor College of Medicine 1991-1992 : Research Associate, Department of Neurology, Baylor College of Medicine 1992-1993:Instructor, Department of Neurology, Baylor College of Medicine 1993-1999:Assistant Professor, Department of Neurology, Baylor College of Medicine 2000-2005:Associate Professor, Department of Neurology, Baylor College of Medicine 2006-2013:Professor of Neurology, Baylor College of Medicine, Unites States 12/2013-Present:Senior Member and Adjunct Professor of Neuroscience ResearchProgram, Houston Methodist Research Institute and Weill Cornell Medical College of Cornell University, USA
Research Interest
1.Determine the epigenetic mechanisms of chronic hypoxia induced learning and memory deficiency and Alzheimer’s disease neuropathology 2.Understanding the molecular mechanisms of transcription factors Nurr1 and Pitx3, and microRNA-132 regulation in dopaminergic cell differentiation 3.Define the role of dopaminergic neuron development gene defects in Parkinson’s disease 4.Assess the pathological effect of reactive microglia and astrocytes in Parkinson’s disease 5.Investigate the pathological role of autophagy defects in motor neuron degeneration in ALS and other neurodegenerative disorders
Publications
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Jankovic J, Chen S, Le W. (2005) Role of Nurr1 in dopamine neuron development and Parkinson disease. Progress in Neurobiology. 77:128-138
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Deng H, Le W, Jankovic J (2004). Parkinson’s Disease, Essential Tremor, and Premutation Alleles of theFMR1Gene. JAMA 292:1685-1686
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.Le W, Xu P.Y, Jiang H, et al. (2003) Mutations in NNR4A2 associated with familial Parkinson’s disease. Nature Genetics. 33:85-89.
