Lu Xiuli
Professor
School of Life Science
Eastern Liaoning University
China
Biography
U Xiuli, a professor at School of Life Science, Liaoning University, received B.S. in Pharmacology in Chengdu University of Traditional Chinese Medicine in 1997 and Ph. D in Medicine in Nagoya University in2006 respectively, and completed the postdoctoral research in 2008 in Nagoya University in Japan.The goal of our research laboratory is to understand cell signaling transduction related to stress and development of biopharmaceutics. We are focusing on 1) Study of biological function and pathological role of cholesterol in the cells; 2) Study on the stress-related cellular signal transduction under oxidative stress and ER stress at cellular level; 3) Study on the molecular mechanisms and gene therapy of neurodegenerative disease; 4) Study on the interactions between the macromolecules utilizing the molecular simulation.
Research Interest
Alzheimer’s disease,
Publications
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Xiuli Lu, Yang Li, Weiqi Wang, Shuchao Chen, Ting Liu, Dan Jia, Xiaoping Quan, Alan K Chang, Bing Gao,3ï¢-hydroxysteroid-ï„24 reductase(DHCR24) protects neuronal cells from apoptotic cell death induced by endoplasmic reticulum (ER) stress, Plos One, 2014 Jan 29;9(1):e86753 (SCI, IF 4.1)
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Xiaoping Quan, Xiuqiang Chen, Deliang Sun, Bo Xu, Linlin Zhao, Xiaoqian Shi, Hongsheng Liu, Bing Gao, Xiuli Lu，The Mechanism of the Effect of U18666a on Blocking the Activity of 3β-hydroxysterol Δ-24-reductase(DHCR24): Molecular Dynamics Simulation Study and Free Energy Analysis，Journal of Molecular Modeling (SCI 2区, IF 2.3)
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Xiuli Lu, Deliang Sun, Bo Xu, Jichuan Pan，Yanhong Wei, Xu Mao, Daojun Yu, Hongsheng Liu, Bing Gao. In silico screening and molecular dynamic study on nsSNPs associated with kidney stone in SLC26A6 gene. J Urol. 2016 Jan 23. pii: S0022-5347(16)00134-8. ( SCI 2区, IF 4.5)
