Liu,suling

Biography

Nov. 2012~Present, Professor, School of Life Sciences, University of Science and Technology of China, Hefei, Anhui, China Characterizing different states of breast cancer stem cells. Studying the effects of microRNAs on breast cancer stem cell self-renewal and differentiation using Tet-on/off system, mammary fatpad injections and intracardiac injections in mouse models. Studying the regulation of tumor microenvironment on breast cancer stem cell. Oct. 2010~Oct. 2012, Research Assistant Professor, Department of Internal Medicine / Comprehensive Cancer Center, University of Michigan, Ann Arbor, USA. Investigating the combination therapy of PARPi and 17-AAG to target breast cancer stem cells in Triple-negative breast cancers Studying the effects of microRNAs on breast cancer stem cell self-renewal and differentiation using Tet-on/off system, mammary fatpad injections and intracardiac injections in mouse models Oct. 2006~Oct. 2010, Research Investigator, Department of Internal Medicine / Comprehensive Cancer Center, University of Michigan, Ann Arbor, USA. Studying the effects of microRNAs on breast cancer stem cell differentiation using Tet-on/off system, mammary fatpad injections and intracardiac injections in mouse models

Research Interest

Studying the microenvironment (“niche”) of human breast stem cells in both in vitro, co-culture system and in vivo intra-tibia injections Utilizing lentiviral siRNA system to study the role of BRCA1 in human breast stem cell , self-renewal and differentiation in both in vitro and in vivo models Oct. 2003~Sept. 2006, Research Fellow, Department of Internal Medicine / Comprehensive Cancer Center, University of Michigan, Ann Arbor, USA. Utilizing lentiviral systems (knockdown or overexpression) to study the role of, Hedgehog pathway, Notch Pathway and Bmi-1 in human breast stem cell self-renewal and differentiation both in vitro “mammosphere” system and in vivo, NOD/SCID mouse model Identification and Isolation of both normal and cancerous human breast stem cells with cell surface markers by flow cytometry, Mar. 1999~Sept.2003, Graduate student Research Assistant, Department of Vet. Biosciences, The Ohio State University, Columbus, OH, USA Studying the risk of exposure to beef growth promoter in breast cancer Defining the estrogenic regulation mechanism and function of Protein Tyrosine Phosphatse (PTP) gamma, a novel tumor suppressor gene in human breast Indentifying the anticancer potential of a natural compound, Gossypol (GP), and its enatiomers, (+)GP and (-)GP, in human breast cancer.