Chen Haijun
Associate Professor
Department of Chemistry
Fuzhou University
China
Biography
Education and experience ☆ Shanghai Institute of Materia Medica Chinese Academy of Sciences, Dr. 2003.09-2008.07 professional: medicinal chemistry ☆ 1999.09-2003.07 Fuzhou University science and engineering double degree Major: chemical science, bio-engineering work experience ☆ 2013.03- now an associate professor of Chemistry and Chemical Engineering, Fuzhou University ☆ 2011.03 -2013.02 Postdoctoral Fellow , Galveston Medical Division, University of Texas, USA 2008.06-2011.02 ShangPharma Project Leader
Research Interest
Mainly engaged in innovative drug design and structure-activity relationship research, through the active natural product-based drug skeleton for diversity synthesis and derivatization, combined with modern drug structure optimization strategy to explore the structure and activity of drugs, structure and targeting, Sex and other laws, and then develop anti-virus, anti-neurodegenerative diseases and anti-tumor activity of new drugs. In the new small molecule drug design and synthesis has made some achievements in the period of Dr., mainly to carry out anti-hepatitis B virus drug design and synthesis of research work, successfully designed and synthesized with independent intellectual property rights, with a new mechanism of action of non-nucleoside Anti-hepatitis B virus innovative drugs (1.1 new drugs) - isothiofluoride, the candidate drug in 2012 successfully approved into the clinical trials. Chem. Chem. Chem., Eur. J. Med. Chem., Bioorg. Med. Chem., Bioorg. Med. Chem. Chem. Med. Chem., Bio. Med. Chem., Bio. Med. Chem. . Lett. And other pharmaceutical chemistry published more than 40 SCI papers, apply for more than 20 patents, 12 patents granted.
Publications
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42. Chen, H. J.; Wang, W. L.; Wang, G. F.; Shi, L. P.; Gu, M.; Ren, Y. D.; Hou, L. F.; He, P. L.; Zhu, F. H.; Zhong, X. G.; Tang, W.; Zuo, J. P.; Nan, F. J. Rational design and synthesis of 2,2-bisheterocycle tandem derivatives as non-nucleoside hepatitis B virus inhibitors. ChemMedChem, 3, 1316-1321.
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43. Wan, J.; Zhu, Y. N.; Feng, J. Q.; Chen, H. J.; Zhang, R. J.; Ni, J.; Chen, Z. H.; Hou, L. F.; Liu, Q. F.; Zhang, J.; Yang, L.; Tang, W.; Yang, Y. F.; Nan, F. J.; Zhao, W. M.; Zuo,2008, 2008, J. P. Periplocoside A, a pregnane glycoside from Periploca sepium Bge, prevents concanavalin A-induced mice hepatitis through inhibiting NKT-derived inflammatory cytokine productions. Int Immunopharmacol 8, 1248-1256.
