Jingyong Wang
Principal Investigator
Biomedicine and health
GUANGZHOU INSTITUTES OF BIOMEDICINE AND HEALTH
China
Biography
Jinyong Wang joined GIBH in 2012 as a principle investigator , member of 100-talents Program of Chinese Academy of Sciences. Dr. Wang obtained his doctoral degree at Zhejiang University, China. He successively took postdoctoral training at Medical College of Wisconsin, and University of Wisconsin-Madison. His research focus on regulation of hematopoiesis during normal and disease conditions. Dr. Wang is currently a member of American Society of Hematology.
Research Interest
Cells in hematopoietic hierarchy, hematopoietic stem cell (HSC) is the only cell type that can self-renew and generate lifelong supply of all the mature blood cells that maintain the whole hematopoietic system. Understanding of the mechanisms regulating self-renewal, differentiation of HSC is crucial for HSC maintenance, expansion and regeneration. Using in vitro differentiation and animal models, our lab focus on the regulation of hematopoiesis during stress and pathological conditions with emphasis on the role of transcription factors. Besides, the interaction between HSCs and their niches(microenvironment) is also investigated with animal models of hematopoietic malignancies.
Publications
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Xiaoli Chen, Qianhao Zhao, Chen Li, Yang Geng, Ke Huang et al.(2015) OP9-Lhx2 stromal cells facilitate derivation of hematopoietic progenitors both in vitro and in vivo. Stem Cell Research. 15: 395-402.
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Tongjie Wang, Chen Li, Chengxiang Xia, Yong Dong, Dan Yang et al.(2015) Oncogenic NRAS hyper-activates multiple pathways in human cord blood stem/progenitor cells and promotes myelomonocytic proliferation in vivo. Am J Transl Res.7: 1963-1973.
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Uejia Li, Chengxiang Xia, Tongjie Wang, Lijuan Liu, Qianhao Zhao et al.(2017) Pyrimidoindole derivative UM171 enhances derivation of hematopoietic progenitor cells from human pluripotent stem cells. Stem Cell Research. 21: 32-39.
