Jue Shi

Biography

Jue Shi has completed his B.S. in Physics at Zhongshan University, China, PRC, M.A. in Science Education, Ph.D. in Biophysics at the University of Michigan, Ann Arbor, Postdoctoral in Department of Systems Biology, Harvard Medical School

Research Interest

My main research interest is to develop new and more effective cancer therapeutics and treatment strategies by understanding the quantitative mechanisms underlying variation in anticancer drug response in distinct cancer types as well as immune-cancer interactions that modulate various aspects of oncogenesis, metastasis and treatment response. My lab combines quantitative single-cell imaging, ensemble profiling and computational modeling of cellular pathway/network dynamics to uncover novel drug targets, new drug candidates, new immuno-oncology therapeutics and improved combinatorial strategies for cancer treatment. More broadly speaking, my lab aims to answer the fundamental question of how dynamics of signaling molecules and their associated networks/pathways control differential cellular response to specific environmental signals and stress stimuli, and apply the acquired mechanistic understanding to guide development of more effective cancer treatment.