Shuiqiao Yuan
Professor
Department of Reproductive medicine
Huazhong University of Science and Technology
China
Biography
Broadly, my research field lies in aspects of human genetics and reproductive biology with the keen focus on investigating the genetic architecture of human infertility and the function of microRNAs in germ cells source of fertility. During my Ph.D. and Post-doctoral tenures, I greatly enhanced the understanding of the complex infertility genetic causes and focused on the testis and ovary specific expressed gene datasets in an attempt to dissect the genetic architecture of human infertility. During these years, my primary responsibilities included both the design and implementation of the experiments, as well as daily oversight of laboratory technicians. I worked with both graduate and undergraduate students in the laboratory in an advisory capacity on their projects. I have also been an integral part of the analysis teams for numerous past and ongoing projects. My research field focused on the molecular structure, genetic defect, and related small non-coding RNAs in germ cells. I have an extensive track record in human reproductive biology and have developed an international reputation among peers. In the last 10 years of my research experience, I have published numerous high-impact papers on male and female genetic infertility discoveries and their regulations in the most prestigious scientific journals such as PNAS, EMBO J, Development, Scientific Reports, PLoS One, Biology of Reproduction, and Molecular Reproduction and Development etc.
Research Interest
Genetic and epigenetic regulation in germ cell〠Mechanism of spermatogenesis and oogenesis〠Genome editing
Publications
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Shuiqiao Yuan, Andrew Schuster, Chong Tang, Tian Yu, Nicole Ortogero, Jianqiang Bao, Huili Zheng, Wei Yan. Sperm-borne miRNAs and endo-siRNAs are important for fertilization and preimplantation embryonic development. Development, 2016, 143(4):635-47. (IF=6.46)
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Fededa JP, Esk C, Mierzwa B, Stanyte R, Yuan S, Zheng H, Ebnet K, Yan W, Knoblich JA, Gerlich DW.MicroRNA-34/449 controls mitotic spindle orientation during mammalian cortex development. EMBO J. 2016 Nov 15;35(22):2386-2398.(IF=9.79)
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Yanagimachi R, Harumi T, Matsubara H, Yan W, Yuan S, Hirohashi N, Iida T, Yamaha E, Arai K, Matsubara T, Andoh T, Vines C, Cherr GN. Chemical and physical guidance of fish spermatozoa into the egg through the micropyle. Biol Reprod. 2017 Apr 1;96(4):780-799.(IF=3.46)
