Jiake Xu
University fellow
Department of Osteoimmunology
Institute for Advancing Translational Medicine in Bone and Joint Disease
China
Biography
"Academic qualifications: 1980.9-1985.7 B. Med Guangzhou Medical University, Guangzhou, China 1991.2-1994.12 Ph.D School of Pathology and Laboratory Medicine, The University of Western Australia, Australia Previous academic positions held: 1994.12-1998.5 Postdoctoral Fellow School of Medicine, Stanford University 1998.5-2001.2 Research Associate School of Surgery and Pathology, The University of Western Australia, Australia 2001.3-2003.3 Research Follow/Head of Lab School of Surgery and Pathology, The University of Western Australia, Australia 2003.3-2007.3 Senior Lecturer/Head of Lab School of Surgery and Pathology, The University of Western Australia, Australia 2007.3-2009.3 Asso. Professor/Head of Lab School of Surgery and Pathology, The University of Western Australia, Australia 2009.3-2011.3 Professor//Head of Lab School of Surgery and Pathology, The University of Western Australia, Australia Present academic position: 2011.3- Winthrop Professor /Head of Lab School of Pathology and Laboratory Medicine, The University of Western Australia, Australia 2014.8- University Fellow Institute for Advancing Translational Medicine in Bone & Joint Diseases, Hong Kong Baptist University"
Research Interest
"Technical expertise Osteoimmunology, osteolysis, and mechanisms of bone resorption Research area RANKL signalling transduction pathways and transcription program Screening of natural compounds for the treatment of osteoporosis Deciphering the molecular basis of musculoskeletal diseases using ENU-induced mutant mice Osteoclast and osteoblast intercellular communication"
Publications
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S L Rea (nee Morgan), Walsh JP, Ward L, Ward BK, Kent GN, Xu J, Ratajczak T. (2006) A Novel Mutation (K378X) in the Sequestosome 1 Gene Associated with Increased NF-κB signalling and Paget’s disease of bone with a Severe Phenotype. J Bone Miner Res. 21:1136-45.
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Yip KHM, Zheng MH, Steer JH, Giardina TM, Han R, Lo SZ, Bakker AJ, Cassady AI, Joyce DA, Xu J (2005) Thapsigargin (TG) modulates osteoclastogenesis via the regulation of RANKL-induced signaling pathways and reactive oxygen species production. J Bone Miner Res.8:1462-71.
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Yip KHM, Zheng HM, Feng HT, Steer JH, Joyce DA, Xu J (2004) Sesquiterpene lactone parthenolide blocks lipopolysaccharide induced osteolysis via the suppression of NF-kB. J Bone Miner Res 19(11):1905-16.