Pan Lifeng
Professor
Department of Chemistry
Institute of Organic Chemistry
China
Biography
ducation and Appointments： 　　Sep. 2001 ~ Jul. 2005, B.Sc., Department of Chemistry, Fudan University, Shanghai, China 　　Sep. 2005 ~ Jun. 2010, Ph.D., Department of Biochemistry, The Hong Kong University of Science and Technology, Hong Kong 　　Sep. 2010 ~ Feb. 2011, Research Associate, Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong 　　Mar. 2011 ~ Aug. 2012, Research Assistant Professor, Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong 　　Jan. 2013 ~ Apr. 2013, Visiting Scholar, Cell Biology Department, Harvard Medicine School, Harvard University, USA 　　Aug. 2012 ~ present, “Bairen Jihua” Professor, State Key Laboratory of Bioorganic and Natural Product Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, China
Research Interest
1.Multidisciplinary study of important biological questions related to human diseases by combing structure biology (NMR together with X-ray crystallography), biochemistry, cell biology and organic chemistry, including: Structural and functional studies of macromolecular complexes important in autophagy and necroptosis; Investigation of the molecular principles concerning the biogenesis and function of cilia, as well as the disease mechanism of ciliopathies; Mechanistic studies of neurodegenerative diseases. 2.Bioactive small molecules related chemical biology studies, including: Mechanistic studies of natural small molecules and biological targets interactions; SAR-by-NMR based bioactive small molecules screen, optimization and additional drug design related to human cancer and immunity. 3.Develop and application of novel NMR based screening methods for bioactive compounds.
Publications
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Wen, W., Yu, J., Pan, L., Wei, Z., Weng, J., Wang, W., Yan, S., Tran, T., Hong, W., and Zhang, M.* (2010) "Lipid-induced Conformational Switch Controls Fusion Activity of Longin Domain SNARE Ykt6" Mol. Cell,37, 383-395
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Pan, L., Yan, J., Wu, L., and Zhang, M.* (2009) "Assembling Stable Hair-Cell Tip Link Complex via Multi-dentate Interactions between Harmonin and Cadherin23" PNAS. 106, 5575-5580.
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Chen, J.#, Pan, L.#, Wei, Z., Zhao, Y., and Zhang, M.* (2008) "Domain Swapped Dimerization of ZO-1 PDZ2 Generates Specific and Regulatory Connexin43 Binding Sites" EMBO J, 27, 2113-2123. (#: co-first authors)
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Pan, L, Wu, H., Shen, C., Shi, Y., Jin, W., Xia, J., and Zhang, M.* (2007) "Clustering and synaptic targeting of PICK1 requires direct interaction between the PDZ domain and lipid membranes." EMBO J, 26, 4576-4587.
