Li Yan
Professor
State Key Laboratory of Phytochemisty
Kunming Institute of Botany
China
Biography
LI Yan, Professor of molecular pharmacology. The major research of our group is screening, research and development of new anticancer drugs from the natural compounds, investigating their action mechanisms andevaluating in vivo activity with xenograft mouse model. We are also focused our research and drug discovery on certain signaling pathways which are closely related with tumorigenesis, such as WNT pathway in colon tumor and mTOR pathway in breast tumor.We are aiming tofind anti-tumor lead compounds and novel potential drug targets for cancer therapy.
Research Interest
Molecular Pharmacology
Publications
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Yu C, Gong Y, Zhou H, Wang M, Kong L, Liu J, An T, Zhu H, Li Y. Star-PAP, a poly (A) polymerase, functions as a tumor suppressor in an orthotopic human breast cancer model. Cell death & disease. 2017 Feb;8(2):e2582.
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Zhou H, Shang C, Wang M, Shen T, Kong L, Yu C, Ye Z, Luo Y, Liu L, Li Y, Huang S. Ciclopirox olamine inhibits mTORC1 signaling by activation of AMPK. Biochemical pharmacology. 2016 Sep 15;116:39-50.
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Wang M, Zhou A, An T, Kong L, Yu C, Liu J, Xia C, Zhou H, Li Y. N-Hydroxyphthalimide exhibits antitumor activity by suppressing mTOR signaling pathway in BT-20 and LoVo cells. Journal of Experimental & Clinical Cancer Research. 2016 Mar 3;35(1):41.
