Lin Xu
Principle Investigator
Key Lab of Animal Models and Human Disease Mechanisms
Kunming Institute of Zoology
China
Biography
Prof. Lin Xu, Principle Investigator and Director, Key Lab of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences. Major interest is to study the hippocampal circuitry in the processes of memory and neuropsychiatric disorders such as Alzheimer’s disease, drug addiction, major depression, autism, posttraumatic stress disorder etc.; Techniques routinely used are behavior, pharmacology, PET, optogenetic, multi-electrode array recording for spikes and synaptic plasticity, immmunohistology, western blots and expression profiles etc.; By taking the advantage of plentiful diverse natural products in Yunnan and animal models to develop novel drugs for the treatment of neuropsychiatric disorders. Over 70 papers were published in Natureã€PNASã€Neuronã€Cellã€JNS ã€Biol Psychiatry. Winner of NSFC “Distinguished Young Scientists” and CAS “Hundred Talents Project”; Chief scientist of 973 Project “The function and Mechanism of Forgetting”; Principal investigator of Strategic Priority Research Program of the Chinese Academy of Science “The brain function mapping of learning and memory and Alzheimer’s disease ”, Filed a number of domestic and foreign patents. Over 40 students got MSc or PhD.
Research Interest
Hippocampal circuitry in the processes of memory and neuropsychiatric disorders such as Alzheimer’s disease, drug addiction, major depression, autism, posttraumatic stress disorder
Publications
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Wang J, Chai A, Zhou Q, Lv L, Wang L, Yang Y, Xu L. Chronic clomipramine treatment reverses core symptom of depression in subordinate tree shrews. PloS one. 2013 Dec 2;8(12):e80980.
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Wang M, Yang Y, Dong Z, Cao J, Xu L. NR2B-containing N-methyl-D-aspartate subtype glutamate receptors regulate the acute stress effect on hippocampal long-term potentiation/long-term depression in vivo. Neuroreport. 2006 Aug 21;17(12):1343-6.
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Yang J, Han H, Cao J, Li L, Xu L. Prenatal stress modifies hippocampal synaptic plasticity and spatial learning in young rat offspring. Hippocampus. 2006 Jan 1;16(5):431-6.
