Xu-dong Zhao
Principal Investigator
Tumor Stem Cell
Kunming Institute of Zoology
China
Biography
Prof. Xu-Dong Zhao, Principle Investigator, Lab of Tumor Stem Cell. Dr. Xudong Zhao has been working in the field of cancer and stem cell related research. He made the important discovery that a recently discovered gene, namely HUWE1, binds and promotes the degradation of N-Myc. He generated Huwe1 conditional knockout embryonic stem cells and used them to study neural differentiation. He also studied the role of Id genes in the maintenance of neural and glioblastoma stem cell by generating Id1-Id2-Id3 triple knockout mice and found Id genes enable the attachment of stem cell to niche by inhibiting Rap1Gap expression. 13 papers have been published in Nat Cell Biol, Dev Cell, J Clin Invest, PNAS, etc.
Research Interest
Molecular mechanisms of cancer development and anti-cancer drug screening by utilizing cancer stem cell and animal models
Publications
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Hui-Fang ZH, ZHANG YX, Xu-Dong ZH. Animal models of human glioma: the progress of application and investigation.
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Liu T, Guo Y, Yan L, Sun B, Zheng P, Zhao X. Depletion of endogenous germ cells in tree shrews in preparation for spermatogonial transplantation. Experimental and Therapeutic Medicine. 2017 Sep 1;14(3):2349-54.
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Li CH, Yan LZ, Ban WZ, Tu Q, Wu Y, Wang L, Bi R, Ji S, Ma YH, Nie WH, Lv LB. Long-term propagation of tree shrew spermatogonial stem cells in culture and successful generation of transgenic offspring. Cell Research. 2017 Feb 1;27(2):241-52.
